Covimectin 12 mg Tablets

💊 Covimectin 12 mg Tablet – Overview

Covimectin 12 mg contains Ivermectin, a widely used antiparasitic medicine that kills and paralyzes certain parasites and worms in the body.

⚙️ Mechanism of Action

Ivermectin in Covimectin works by:

• Binding to glutamate-gated chloride ion channels in nerve and muscle cells of parasites.

• This causes an increase in cell membrane permeability to chloride ions → paralysis and death of the parasite.

• It selectively targets parasites, not humans, due to differences in the nervous system structure.

🧬 Medical Uses / Indications

Covimectin 12 mg is prescribed for the treatment of the following parasitic infections:

Strongyloidiasis
Intestinal infection caused by Strongyloides stercoralis (threadworm)

Onchocerciasis (River Blindness)
Caused by Onchocerca volvulus

Scabies
Skin infestation by mites (Sarcoptes scabiei)

Pediculosis (Head Lice)
Infestation by Pediculus humanus capitis

Filariasis (adjunct therapy)
Supportive treatment for Wuchereria bancrofti infection

Cutaneous larva migrans
Skin infection due to hookworm larvae (off-label use)

📏 Dosage and Administration

Typical Adult Dose:

• 200 micrograms per kg body weight (200 µg/kg) as a single dose

• Usually taken on an empty stomach with water.

For Scabies:

• 200 µg/kg orally once,

• Repeat after 7–14 days if needed (to kill newly hatched mites).

For Strongyloidiasis:

• 200 µg/kg orally once.

• Sometimes repeated after 2 weeks if infection persists.

⏰ How to Take

• Take the tablet on an empty stomach (1 hour before or 2 hours after food).

• Swallow whole with a glass of water.

• Do not crush or chew.

• If you miss a dose, take it as soon as possible (if prescribed for multiple doses).

⚠️ Side Effects

Common (Mild)

• Headache

• Nausea, vomiting, diarrhea

• Dizziness or fatigue

• Itching or rash (often due to parasite death)

• Muscle or joint pain

Uncommon / Serious

• Fever, swelling of lymph nodes (Mazzotti reaction)

• Low blood pressure

• Rapid heartbeat

• Liver enzyme elevation

• Allergic reaction (rash, swelling, breathing difficulty – rare)

If severe symptoms appear, seek medical help immediately.

🚫 Contraindications

Do not use Covimectin 12 mg if:

• You are allergic to ivermectin.

• You are under 15 kg body weight or under 5 years of age.

• You have severe liver disease.

• You are pregnant or breastfeeding (unless prescribed by a doctor).

🔄 Drug Interactions

Use caution if you are taking:

• Warfarin → may increase risk of bleeding.

• Other CNS depressants (like alcohol, sedatives).

• Certain antibiotics (e.g., clarithromycin, erythromycin) – may increase ivermectin levels.

Always inform your doctor about all medicines and supplements you use.

🧴 Storage Instructions

• Store in a cool, dry place (below 30°C).

• Keep away from direct sunlight and moisture.

• Keep out of reach of children.

🧠 Key Points to Remember

• Covimectin 12 mg is not an antibiotic or antiviral drug.

• Do not use veterinary ivermectin formulations — they are toxic to humans.

• Use only under medical supervision.

• For scabies or lice, all household contacts may need treatment to prevent reinfection.